Effect of Enhancers on in vitro and in vivo Skin Permeation and Deposition of S-Methyl-_L-Methionine.

ABSTRACT: S-methyl-_L-methionine (SMM), also known as vitamin U, is commercially available as skin care cosmetic products for its wound healing and photoprotective effects. However, the low skin permeation expected of SMM due to its hydrophilic nature with a log P value of -3.3, has not been thoroughly addressed. The purpose of this study thus was to evaluate the effect of skin permeation enhancers on the skin permeation/deposition of SMM. Among the enhancers tested for the in vitro skin permeation and deposition of SMM, oleic acid showed the most significant enhancing effect. Moreover, the combination of oleic acid and ethanol further enhanced in vitro permeation and deposition of SMM through hairless mouse skin. Furthermore, the combination of oleic acid and ethanol signifi

SUBMITTER: Kim KT 

PROVIDER: S-EPMC5499623 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature