Indirect Pathway of Caudal Basal Ganglia for Rejection of Valueless Visual Objects.

ABSTRACT: The striatum controls behavior in two ways: facilitation and suppression through the direct and indirect pathways, respectively. However, it is still unclear what information is processed in these pathways. To address this question, we studied two pathways originating from the primate caudate tail (CDt). We found that the CDt innervated the caudal-dorsal-lateral part of the substantia nigra pars reticulata (cdlSNr), directly or indirectly through the caudal-ventral part of the globus pallidus externus (cvGPe). Notably, cvGPe neurons receiving inputs from the CDt were mostly visual neurons that encoded stable reward values of visual objects based on long-past experiences. Their dominant response was inhibition by valueless objects, which generated disinhibition of cdlSNr neurons and inhibit

SUBMITTER: Kim HF 

PROVIDER: S-EPMC5499676 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature