Microchip-based 3D-Cell Culture Using Polymer Nanofibers Generated by Solution Blow Spinning.

ABSTRACT: Polymer nano/micro fibers have found many applications including 3D cell culture and the creation of wound dressings. The fibers can be produced by a variety of techniques that include electrospinning, the primary disadvantage of which include the requirement for a high voltage supply (which may cause issues such as polymer denaturation) and lack of portability. More recently, solution blow spinning, where a high velocity sheath gas is used instead of high voltage, has been used to generate polymer fibers. In this work, we used blow spinning to create nano/microfibers for microchip-based 3D cell culture. First, we thoroughly investigated fiber generation from a 3D printed gas sheath device using two polymers that are amenable to cell culture (polycaprolactone, PCL and polystyrene, PS) as w

SUBMITTER: Chen C 

PROVIDER: S-EPMC5499714 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature