Circadian oscillations of microbial and functional composition in the human salivary microbiome.

ABSTRACT: The human microbiomes across the body evidently interact with various signals in response to biogeographical physiological conditions. To understand such interactions in detail, we investigated how the salivary microbiome in the oral cavity would be regulated by host-related signals. Here, we show that the microbial abundance and gene participating in keeping the human salivary microbiome exhibit global circadian rhythm. Analysis of the 16S rRNA sequences of salivary microbial samples of six healthy adults collected at 4-h intervals for three days revealed that the microbial genera accounting for 68.4-89.6% of the total abundance were observed to significantly oscillate with the periodicity of ∼24 h. These oscillation patterns showed high variations amongst individuals, and the extent of c

SUBMITTER: Takayasu L 

PROVIDER: S-EPMC5499806 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature