PosiGene: automated and easy-to-use pipeline for genome-wide detection of positively selected genes.

ABSTRACT: Many comparative genomics studies aim to find the genetic basis of species-specific phenotypic traits. A prevailing strategy is to search genome-wide for genes that evolved under positive selection based on the non-synonymous to synonymous substitution ratio. However, incongruent results largely due to high false positive rates indicate the need for standardization of quality criteria and software tools. Main challenges are the ortholog and isoform assignment, the high sensitivity of the statistical models to alignment errors and the imperative to parallelize large parts of the software. We developed the software tool PosiGene that (i) detects positively selected genes (PSGs) on genome-scale, (ii) allows analysis of specific evolutionary branches, (iii) can be used in arbitrary species con

SUBMITTER: Sahm A 

PROVIDER: S-EPMC5499814 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature