A Dynamic Transmission Model to Evaluate the Effectiveness of Infection Control Strategies.

ABSTRACT:

Background

The advancement of knowledge about control of antibiotic resistance depends on the rigorous evaluation of alternative intervention strategies. The STAR*ICU trial examined the effects of active surveillance and expanded barrier precautions on acquisition of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) in intensive care units. We report a reanalyses of the STAR*ICU trial using a Bayesian transmission modeling framework.

Methods

The data included admission and discharge times and surveillance test times and results. Markov chain Monte Carlo stochastic integration was used to estimate the transmission rate, importation, false negativity, and clearance separately for MRSA and VRE. The primary outcome was the interventio

SUBMITTER: Khader K 

PROVIDER: S-EPMC5499871 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature