The effect of circulating miR-223 on surveillance of different cancers: a meta-analysis.

ABSTRACT:

Purpose

Abnormal expression of miR-223 in cancerous tissue has confirmed it as an important player in tumorigenesis of cancers, such as hepatocellular carcinoma, colorectal carcinoma, osteosarcoma, gastric cancer, and chronic lymphocytic leukemia. The present meta-analysis aimed to explore the association between circulating miR-223 and prognosis of cancers.

Methods

The studies were accessed by an electronic search of multiple databases. RevMan5.3 and STATA14.0 were used to estimate the heterogeneity among studies, pooled effects, and publication bias.

Results

Ten studies with data of 1,002 patients with cancer were included in this meta-analysis. The risk of metastasis from stages 3 to 4 of TNM did not decrease when high versus low circulating expression of miR-223 w

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5499933 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature