Incidence of small bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy.

ABSTRACT:

Background and study aims

Lynch syndrome (LS) patients have an increased risk of small bowel cancer. The question is whether surveillance will lead to early detection of (pre)malignant lesions. We recently reported on prevalence of small bowel neoplasia (SBN) in LS patients as assessed by video capsule endoscopy (VCE). The aim of this prospective study was to determine the incidence of SBN.

Patients and methods

Asymptomatic LS patients who underwent a VCE were invited to undergo a second VCE procedure 2 years later. If abnormalities or polypoid lesions larger than 1 cm were detected, subsequent endoscopic procedures were performed.

Results

A total of 155 (78 %) of the initial 200 patients underwent a second VCE procedure after a mean of 2.2 (range 1 - 6) years. In 17

SUBMITTER: Haanstra JF 

PROVIDER: S-EPMC5500106 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature