Host Genome Influence on Gut Microbial Composition and Microbial Prediction of Complex Traits in Pigs.

ABSTRACT: The aim of the present study was to analyze the interplay between gastrointestinal tract (GIT) microbiota, host genetics, and complex traits in pigs using extended quantitative-genetic methods. The study design consisted of 207 pigs that were housed and slaughtered under standardized conditions, and phenotyped for daily gain, feed intake, and feed conversion rate. The pigs were genotyped with a standard 60 K SNP chip. The GIT microbiota composition was analyzed by 16S rRNA gene amplicon sequencing technology. Eight from 49 investigated bacteria genera showed a significant narrow sense host heritability, ranging from 0.32 to 0.57. Microbial mixed linear models were applied to estimate the microbiota variance for each complex trait. The fraction of phenotypic variance explained by the microb

SUBMITTER: Camarinha-Silva A 

PROVIDER: S-EPMC5500156 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature