Resolving the Complex Genetic Basis of Phenotypic Variation and Variability of Cellular Growth.

ABSTRACT: In all organisms, the majority of traits vary continuously between individuals. Explaining the genetic basis of quantitative trait variation requires comprehensively accounting for genetic and nongenetic factors as well as their interactions. The growth of microbial cells can be characterized by a lag duration, an exponential growth phase, and a stationary phase. Parameters that characterize these growth phases can vary among genotypes (phenotypic variation), environmental conditions (phenotypic plasticity), and among isogenic cells in a given environment (phenotypic variability). We used a high-throughput microscopy assay to map genetic loci determining variation in lag duration and exponential growth rate in growth rate-limiting and nonlimiting glucose concentrations, using segregants fr

SUBMITTER: Ziv N 

PROVIDER: S-EPMC5500157 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature