Trends in DNA Methylation with Age Replicate Across Diverse Human Populations.

ABSTRACT: Aging is associated with widespread changes in genome-wide patterns of DNA methylation. Thousands of CpG sites whose tissue-specific methylation levels are strongly correlated with chronological age have been previously identified. However, the majority of these studies have focused primarily on cosmopolitan populations living in the developed world; it is not known if age-related patterns of DNA methylation at these loci are similar across a broad range of human genetic and ecological diversity. We investigated genome-wide methylation patterns using saliva- and whole blood-derived DNA from two traditionally hunting and gathering African populations: the Baka of the western Central African rain forest and the ≠Khomani San of the South African Kalahari Desert. We identified hundreds of CpG

SUBMITTER: Gopalan S 

PROVIDER: S-EPMC5500158 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature