Hematopoietic progenitor cell mobilization is more robust in healthy African American compared to Caucasian donors and is not affected by the presence of sickle cell trait.

ABSTRACT:

Background

Granulocyte-colony-stimulating factor (G-CSF)-stimulated hematopoietic progenitor cells (HPCs) collected by apheresis have become the predominant graft source for HPC transplantation in adults. Among healthy allogeneic donors, demographic characteristics (age, sex, body mass index [BMI]) and baseline hematologic counts affect HPC mobilization, leading to variability in CD34+ apheresis yields. Racial differences in HPC mobilization are less well characterized.

Study design and methods

We retrospectively analyzed data from 1096 consecutive G-CSF-stimulated leukapheresis procedures in healthy allogeneic African American (AA) or Caucasian donors.

Results

In a multivariate analysis, after adjusting for age, sex, BMI, baseline platelet and mononuclear cell counts

SUBMITTER: Panch SR 

PROVIDER: S-EPMC5500229 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature