Effect of APOE ε4 allele on survival and fertility in an adverse environment.

ABSTRACT:

Background

The apolipoprotein-ε4 allele (APOE-ε4) is strongly associated with detrimental outcomes in affluent populations including atherosclerotic disease, Alzheimer's disease, and reduced lifespan. Despite these detrimental outcomes, population frequencies of APOE-ε4 are high. We hypothesize that the high frequency of APOE-ε4 was maintained because of beneficial effects during evolution when infectious pathogens were more prevalent and a major cause of mortality. We examined a rural Ghanaian population with a high pathogen exposure for selective advantages of APOE-ε4, to survival and or fertility.

Methods and findings

This rural Ghanaian population (n = 4311) has high levels of mortality from widespread infectious diseases which are the main cause of death. We examined wh

SUBMITTER: van Exel E 

PROVIDER: S-EPMC5500260 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature