Human bone marrow harbors cells with neural crest-associated characteristics like human adipose and dermis tissues.

ABSTRACT: Adult neural crest stem-derived cells (NCSC) are of extraordinary high plasticity and promising candidates for use in regenerative medicine. Several locations such as skin, adipose tissue, dental pulp or bone marrow have been described in rodent, as sources of NCSC. However, very little information is available concerning their correspondence in human tissues, and more precisely for human bone marrow. The main objective of this study was therefore to characterize NCSC from adult human bone marrow. In this purpose, we compared human bone marrow stromal cells to human adipose tissue and dermis, already described for containing NCSC. We performed comparative analyses in terms of gene and protein expression as well as functional characterizations. It appeared that human bone marrow, similarly

SUBMITTER: Coste C 

PROVIDER: S-EPMC5500284 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature