Estimated glomerular filtration rate and urine biomarkers in patients with single-ventricle Fontan circulation.

ABSTRACT:

Objectives

To define whether adults with a Fontan circulation, who have lifelong venous congestion and limited cardiac output, have impaired glomerular filtration rate (GFR) or elevated urinary biomarkers of kidney injury.

Methods

We measured circulating cystatin C and creatinine (n=70) and urinary creatinine, albumin, kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL) and N-acetyl glucosaminidase (NAG) (n=59) in ambulatory adult Fontan patients and 20 age-matched and sex-matched controls. Urinary biomarkers were normalised to urine creatinine concentration. Survival free from non-elective cardiovascular hospitalisation was compared by estimated GFR and urinary biomarker levels using survival analysis.

Results

Cystatin C GFR was lower

SUBMITTER: Opotowsky AR 

PROVIDER: S-EPMC5500305 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature