Validation of glomerular filtration rate-estimating equations in Chinese children.

ABSTRACT:

Background

Glomerular filtration rate (GFR) is essential for renal function evaluation and classification of chronic kidney disease (CKD), while the reference method in children are cumbersome. In the Chinese children, there was no data about GFR measured through plasma or renal clearance of the exogenous markers, and therefore no validated GFR-estimating tools in this population.

Methods

We measured GFR with double-sample plasma clearance of 99mTc-DTPA (mGFR) in 87 hospitalized children with renal injury. Using mGFR as the golden standard, we evaluate the efficiency of four different GFR estimation equations (the original and update Schwartz equation, the Filler equation, the CKiD equation) by statistical parameters of correlation, precision and accuracy.

Results

In

SUBMITTER: Zheng K 

PROVIDER: S-EPMC5500331 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature