Identification of prognostic collagen signatures and potential therapeutic stromal targets in canine mammary gland carcinoma.

ABSTRACT: Increasing evidence indicates that the tumor microenvironment plays a critical role in regulating the biologic behavior of breast cancer. In veterinary oncology, there is a need for improved prognostic markers to accurately identify dogs at risk for local and distant (metastatic) recurrence of mammary gland carcinoma and therefore would benefit from adjuvant therapy. Collagen density and fiber organization have been shown to regulate tumor progression in both mouse and human mammary tumors, with certain collagen signatures predicting poor outcomes in women with breast cancer. We hypothesized that collagen signatures in canine mammary tumor biopsies can serve as prognostic biomarkers and potential targets for treatment. We used second harmonic generation imaging to evaluate fibrillar collag

SUBMITTER: Case A 

PROVIDER: S-EPMC5500345 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature