Evaluation of different serological assays for early diagnosis of leptospirosis in Martinique (French West Indies).

ABSTRACT:

Background

Leptospirosis is a potentially life-threatening but curable zoonosis whose prognosis depends on accurate and timely diagnosis. Because of its non-specific clinical presentation, laboratory testing is essential to confirm the diagnosis. Here, we aimed to assess the performance of two enzyme-linked immunosorbent assays (ELISAs) (ELISA Serion and ELISA-Hb Pasteur) and one immunodot (GenBio) using quantitative PCR (qPCR) as gold standard, instead of the traditional microscopic agglutination test, for the diagnosis of acute leptospirosis in an endemic area.

Methodology/principal findings

Between January 2011 and December 2012, a total of 122 patients were diagnosed with leptospirosis, as confirmed by qPCR at the University Hospital of Martinique. Among them, 103 had at

SUBMITTER: Courdurie C 

PROVIDER: S-EPMC5500375 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature