Calcium Sensor, NCS-1, Promotes Tumor Aggressiveness and Predicts Patient Survival.

ABSTRACT: Neuronal Calcium Sensor 1 (NCS-1) is a multi-functional Ca²⁺-binding protein that affects a range of cellular processes beyond those related to neurons. Functional characterization of NCS-1 in neuronal model systems suggests that NCS-1 may influence oncogenic processes. To this end, the biological role of NCS-1 was investigated by altering its endogenous expression in MCF-7 and MB-231 breast cancer cells. Overexpression of NCS-1 resulted in a more aggressive tumor phenotype demonstrated by a marked increase in invasion and motility, and a decrease in cell-matrix adhesion to collagen IV. Overexpression of NCS-1 was also shown to increase the efficacy of paclitaxel-induced cell death in a manner that was independent of cellular proliferation. To determine the association between N

SUBMITTER: Moore LM 

PROVIDER: S-EPMC5500411 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature