Reducing uncertainty when using knee-specific finite element models by assessing the effect of input parameters.

ABSTRACT: Little is known about knee-specific factors that influence contact mechanics. Finite Element (FE) models offer a powerful tool to study contact mechanics, but there often exists ambiguity in the exact values of the inputs (e.g., tissue properties), which can result in a range of output values. Our objective was to quantify the reduction in the range of output values (defined herein as "uncertainty") from FE models of the human knee joint when known pre-defined values are used for clinically measurable inputs. To achieve this goal, we applied a statistically augmented FE approach to three human cadaveric knees for which full geometric and kinematic data were available. Two sets of conditions were simulated: All model inputs, clinically measurable or not, were varied to represent a "normal"

SUBMITTER: Guo H 

PROVIDER: S-EPMC5500444 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature