Preparation of exenatide-loaded linear poly(ethylene glycol)-brush poly(l-lysine) block copolymer: potential implications on diabetic nephropathy.

ABSTRACT: The poly(ethylene glycol)-b-brush poly(l-lysine) polymer (PEG-b-(PELG₅₀-g-PLL₃)) was synthesized and evaluated as a nanocarrier for prolonging delivery of exenatide through the abdominal subcutaneous injection route. The isoelectric point of exenatide was 4.86, and exenatide could combine with PEG-b-(PELG₅₀-g-PLL₃) polymers via electrostatic interactions at pH 7.4. This polymer was a good candidate for achieving prolonged drug delivery for exenatide, considering its high molecular weight. Besides the physicochemical characterization of the polymer, in vitro and in vivo applications were researched as a sustained exenatide delivery system. In the in vitro release research, 20.16%-76.88% of total exenatide was rel

SUBMITTER: Tong F 

PROVIDER: S-EPMC5500490 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature