Combined Magnetomotive ultrasound, PET/CT, and MR imaging of ⁶⁸Ga-labelled superparamagnetic iron oxide nanoparticles in rat sentinel lymph nodes in vivo.

ABSTRACT: Current methods for intra-surgical guidance to localize metastases at cancer surgery are based on radioactive tracers that cause logistical challenges. We propose the use of a novel ultrasound-based method, magnetomotive ultrasound (MMUS) imaging that employ a nanoparticle-based contrast agent that also may be used for pre-operative PET/MRI imaging. Since MMUS is radiation free, this eliminates the dependence between pre- and intra-operative imaging and the radiation exposure for the surgical staff. This study investigates a hypothetical clinical scenario of pre-operative PET imaging, combined with intra-operative MMUS imaging, implemented in a sentinel lymph node (SLN) rat model. At one-hour post injection of ⁶⁸Ga-labelled magnetic nanoparticles, six animals were imaged with co

SUBMITTER: Evertsson M 

PROVIDER: S-EPMC5500498 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature