Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner.

ABSTRACT: A new prototype spectral photon-counting computed tomography (SPCCT) based on a modified clinical CT system has been developed. SPCCT analysis of the energy composition of the transmitted x-ray spectrum potentially allows simultaneous dual contrast agent imaging, however, this has not yet been demonstrated with such a system. We investigated the feasibility of using this system to distinguish gold nanoparticles (AuNP) and an iodinated contrast agent. The contrast agents and calcium phosphate were imaged in phantoms. Conventional CT, gold K-edge, iodine and water images were produced and demonstrated accurate discrimination and quantification of gold and iodine concentrations in a phantom containing mixtures of the contrast agents. In vivo experiments were performed using New Zealand White

SUBMITTER: Cormode DP 

PROVIDER: S-EPMC5500581 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature