Suppressive Effects of Mesenchymal Stem Cells in Adipose Tissue on Allergic Contact Dermatitis.

ABSTRACT:

Background

Allergic contact dermatitis (ACD), which is accelerated by interferon (IFN)-γ and suppressed by interleukin (IL)-10 as regulators, is generally self-limited after removal of the contact allergen. Adipose tissue-derived multipotent mesenchymal stem cells (ASCs) potentially exert immunomodulatory effects. Considering that subcutaneous adipose tissue is located close to the site of ACD and includes mesenchymal stem cells (MSCs), the MSCs in adipose tissue could contribute to the self-limiting course of ACD.

Objective

The aims of the present study were to elucidate the effects of MSCs in adipose tissue on ACD and to examine any cytokine-mediated mechanisms involved.

Methods

Ear thickness in a C57BL/6 mouse model of ACD using contact hypersensitivity (CHS) elici

SUBMITTER: Kikuchi S 

PROVIDER: S-EPMC5500702 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature