Serological Epithelial Component Proteins Identify Intestinal Complications in Crohn's Disease.

ABSTRACT: Crohn's Disease (CD) is a relapsing inflammation of the gastrointestinal tract that affects a young working age population and is increasing in developing countries. Half of all sufferers will experience stricturing or fistulizing intestinal complications that require extensive surgical interventions and neither genes nor clinical risk factors can predict this debilitating natural history. We applied discovery and verification phase studies as part of an NCI-FDA modeled biomarker pipeline to identify differences in the low-mass (<25kDa) blood-serum proteome between CD behavioral phenotypes. A significant enrichment of epithelial component proteins was identified in CD patients with intestinal complications using quantitative proteomic profiling with label-free Liquid Chromatography-Tandem

SUBMITTER: Yau YY 

PROVIDER: S-EPMC5500758 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature