Cytocompatible in situ cross-linking of degradable LbL films based on thiol-exchange reaction.

ABSTRACT: Formation of both mechanically durable and programmably degradable layer-by-layer (LbL) films in a biocompatible fashion has potential applications in cell therapy, tissue engineering, and drug-delivery systems, where the films are interfaced with living cells. In this work, we developed a simple but versatile method for generating in situ cross-linked and responsively degradable LbL films, based on the thiol-exchange reaction, under highly cytocompatible conditions (aqueous solution at pH 7.4 and room temperature). The cytocompatibility of the processes was confirmed by coating individual yeast cells with the cross-linked LbL films and breaking the films on demand, while maintaining the cell viability. In addition, the processes were applied to the controlled release of an anticanc

SUBMITTER: Yang SH 

PROVIDER: S-EPMC5500856 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature