Ontology highlight
ABSTRACT:
SUBMITTER: Torchia J
PROVIDER: S-EPMC5500911 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Cancer cell 20161201 6
We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB ...[more]