GeneBreak: detection of recurrent DNA copy number aberration-associated chromosomal breakpoints within genes.

ABSTRACT: Development of cancer is driven by somatic alterations, including numerical and structural chromosomal aberrations. Currently, several computational methods are available and are widely applied to detect numerical copy number aberrations (CNAs) of chromosomal segments in tumor genomes. However, there is lack of computational methods that systematically detect structural chromosomal aberrations by virtue of the genomic location of CNA-associated chromosomal breaks and identify genes that appear non-randomly affected by chromosomal breakpoints across (large) series of tumor samples. 'GeneBreak' is developed to systematically identify genes recurrently affected by the genomic location of chromosomal CNA-associated breaks by a genome-wide approach, which can be applied to DNA copy number data

SUBMITTER: van den Broek E 

PROVIDER: S-EPMC5500957 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature