Evaluation of immune protection induced by DNA vaccines from Haemaphysalis longicornis paramyosin in rabbits.

ABSTRACT:

Background

Haemaphysalis longicornis is a blood-sucking ectoparasite that can cause diseases by transmitting some pathogens to humans and animals. Paramyosin (Pmy) is an immunomodulatory protein, which plays an important role in immune reactions against parasites. In this study, we evaluated the immune protection elicited by recombinant plasmids encoding H. longicornis Pmy in rabbits.

Results

Rabbits vaccinated with pcDNA3.1(+)-Pmy developed high level of IgG compared to control group, suggesting that humoral immune response was induced by vaccination. On the fourth day after fed on the rabbit, some female adults died and the mortality rate from pcDNA3.1(+)-Pmy group (27.31%) was significantly higher than that of the control group (P < 0.0001). Other female ticks were attach

SUBMITTER: Zhang TT 

PROVIDER: S-EPMC5501075 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature