Genome-wide association study of generalized anxiety symptoms in the Hispanic Community Health Study/Study of Latinos.

ABSTRACT: Although generalized anxiety disorder (GAD) is heritable and aggregates in families, no genomic loci associated with GAD have been reported. We aimed to discover potential loci by conducting a genome-wide analysis of GAD symptoms in a large, population-based sample of Hispanic/Latino adults. Data came from 12,282 participants (aged 18-74) in the Hispanic Community Health Study/Study of Latinos. Using a shortened Spielberger Trait Anxiety measure, we analyzed the following: (i) a GAD symptoms score restricted to the three items tapping diagnostic features of GAD as defined by DSM-V; and (ii) a total trait anxiety score based on summing responses to all ten items. We first calculated the heritability due to common variants (h²_SNP ) and then conducted a genome-wide assoc

SUBMITTER: Dunn EC 

PROVIDER: S-EPMC5501086 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature