Ivermectin susceptibility and sporontocidal effect in Greater Mekong Subregion Anopheles.

ABSTRACT:

Background

Novel vector control methods that can directly target outdoor malaria transmission are urgently needed in the Greater Mekong Subregion (GMS) to accelerate malaria elimination and artemisinin resistance containment efforts. Ivermectin mass drug administration (MDA) to humans has been shown to effectively kill wild Anopheles and suppress malaria transmission in West Africa. Preliminary laboratory investigations were performed to determine ivermectin susceptibility and sporontocidal effect in GMS Anopheles malaria vectors coupled with pharmacokinetic models of ivermectin at escalating doses.

Methods

A population-based pharmacokinetic model of ivermectin was developed using pre-existing data from a clinical trial conducted in Thai volunteers at the 200 µg/kg dose. To

SUBMITTER: Kobylinski KC 

PROVIDER: S-EPMC5501099 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature