Uncovering missing pieces: duplication and deletion history of arrestins in deuterostomes.

ABSTRACT:

Background

The cytosolic arrestin proteins mediate desensitization of activated G protein-coupled receptors (GPCRs) via competition with G proteins for the active phosphorylated receptors. Arrestins in active, including receptor-bound, conformation are also transducers of signaling. Therefore, this protein family is an attractive therapeutic target. The signaling outcome is believed to be a result of structural and sequence-dependent interactions of arrestins with GPCRs and other protein partners. Here we elucidated the detailed evolution of arrestins in deuterostomes.

Results

Identity and number of arrestin paralogs were determined searching deuterostome genomes and gene expression data. In contrast to standard gene prediction methods, our strategy first detects exons situa

SUBMITTER: Indrischek H 

PROVIDER: S-EPMC5501109 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature