M₁ muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons.

ABSTRACT: The dorsolateral striatum is critically involved in movement control and motor learning. Striatal function is regulated by a variety of neuromodulators including acetylcholine. Previous studies have shown that cholinergic activation excites striatal principal projection neurons, medium spiny neurons (MSNs), and this action is mediated by muscarinic acetylcholine subtype 1 receptors (M₁) through modulating multiple potassium channels. In the present study, we used electrophysiology techniques in conjunction with optogenetic and pharmacological tools to determine the long-term effects of striatal cholinergic activation on MSN intrinsic excitability. A transient increase in acetylcholine release in the striatum by optogenetic stimulation resulted in a long-lasting increase in excit

SUBMITTER: Lv X 

PROVIDER: S-EPMC5501169 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature