ADAMTS13 Retards Progression of Diabetic Nephropathy by Inhibiting Intrarenal Thrombosis in Mice.

ABSTRACT:

Objective

ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type I repeats-13) prevents microvascular thrombosis by cleaving prothrombogenic ultralarge von Willebrand factor (VWF) multimers. Clinical studies have found association between reduced ADAMTS13-specific activity, ultralarge VWF multimers, and thrombotic angiopathy in patients with diabetic nephropathy. It remains unknown, however, whether ADAMTS13 deficiency or ultralarge VWF multimers have a causative effect in diabetic nephropathy.

Approach and results

The extent of renal injury was evaluated in wild-type (WT), Adamts13^-/- and Adamts13^-/-Vwf^-/- mice after 26 weeks of streptozotocin-induced diabetic nephropathy. We found that WT diabetic mice exh

SUBMITTER: Dhanesha N 

PROVIDER: S-EPMC5501287 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature