Regulatory T-Cell Augmentation or Interleukin-17 Inhibition Prevents Calcineurin Inhibitor-Induced Hypertension in Mice.

ABSTRACT: The immunosuppressive calcineurin inhibitors cyclosporine A and tacrolimus alter T-cell subsets and can cause hypertension, vascular dysfunction, and renal toxicity. We and others have reported that cyclosporine A and tacrolimus decrease anti-inflammatory regulatory T cells and increase proinflammatory interleukin-17-producing T cells; therefore, we hypothesized that inhibition of these effects using noncellular therapies would prevent the hypertension, endothelial dysfunction, and renal glomerular injury induced by calcineurin inhibitor therapy. Daily treatment of mice with cyclosporine A or tacrolimus for 1 week significantly decreased CD4⁺/FoxP3⁺ regulatory T cells in the spleen and lymph nodes, as well as induced hypertension, vascular injury and dysfunction, and

SUBMITTER: Chiasson VL 

PROVIDER: S-EPMC5501301 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature