Development of europium doped core-shell silica cobalt ferrite functionalized nanoparticles for magnetic resonance imaging.

ABSTRACT: The size, shape and chemical composition of europium (Eu³⁺) cobalt ferrite (CFEu) nanoparticles were optimized for use as a "multimodal imaging nanoprobe" for combined fluorescence and magnetic resonance bioimaging. Doping Eu³⁺ ions into a CF structure imparts unique bioimaging and magnetic properties to the nanostructure that can be used for real-time screening of targeted nanoformulations for tissue biodistribution assessment. The CFEu nanoparticles (size ∼7.2nm) were prepared by solvothermal techniques and encapsulated into poloxamer 407-coated mesoporous silica (Si-P407) to form superparamagnetic monodisperse Si-CFEu nanoparticles with a size of ∼140nm. Folic acid (FA) nanoparticle decoration (FA-Si-CFEu, size ∼140nm) facilitated monocyte-derived macrophage (MDM)

SUBMITTER: Kevadiya BD 

PROVIDER: S-EPMC5501313 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature