Circulating fetuin-A levels are not affected by short and long-term energy deprivation and/or by leptin administration.

ABSTRACT:

Objective

Fetuin-A may mediate cross-talk between the liver and adipose tissue. We studied the physiologic regulation of fetuin-A and explored its potential regulation by leptin.

Design and methods

Fetuin-A levels were measured in three interventional studies as well as in in vitro experiments. Study 1: 15 lean subjects received placebo or physiologic replacement-dose recombinant human leptin (metreleptin) following short term complete caloric deprivation to induce severe hypoleptinemia; Study 2: 7 women with relative leptin deficiency due to strenuous exercise or low weight received 3 months of metreleptin; Study 3: 17 women with relative leptin deficiency were randomized to receive metreleptin or placebo over 9 months. In study 4 human hepatoma Hep G2 cells were treated wi

SUBMITTER: Hwang JJ 

PROVIDER: S-EPMC5501325 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature