Which immunotherapy product is better for patients allergic to Polistes venom? A laboratory and clinical study.

ABSTRACT:

Background

Venom immunotherapy (VIT) is highly effective in preventing allergic reactions to insect stings, but the appropriate venom must be used to achieve clinical protection. In patients with multiple positive results to venoms, molecular allergy diagnostics or CAP-inhibition may identify the causative venom. Concerning allergy to venom from Polistes spp. it has been proposed that only the European species P. dominulus should be used for VIT. However, this recommendation is not present in any international guideline. Using both laboratory and clinical data, we aimed to evaluate the reliability of this proposal.

Methods

We performed an in vitro study using CAP-inhibition to determine sensitization of 19 patients allergic to Polistes venom. The clinical study included 191

SUBMITTER: Savi E 

PROVIDER: S-EPMC5501507 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature