The association of ADAM12 polymorphism with osteoarthritis susceptibility: a meta-analysis.

ABSTRACT:

Background

The pathology of osteoarthritis (OA) is partly attributed to genetic factors; however, the role of ADAM12 polymorphism is still controversial. It is necessary to perform a meta-analysis to investigate this possible correlation.

Methods

Case-control studies on the association between OA susceptibility and ADAM12 polymorphism were comprehensively collected by searching PubMed, Embase, and Web of Science. Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled to evaluate OA risk that was possibly conferred by ADAM12 variant. The analyses were performed not only among general population but also in male and female groups.

Results

A total of 8 studies with 10 populations were finally included in this meta-analysis. In the general p

SUBMITTER: Wu Z 

PROVIDER: S-EPMC5501635 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature