LASSIM-A network inference toolbox for genome-wide mechanistic modeling.

ABSTRACT: Recent technological advancements have made time-resolved, quantitative, multi-omics data available for many model systems, which could be integrated for systems pharmacokinetic use. Here, we present large-scale simulation modeling (LASSIM), which is a novel mathematical tool for performing large-scale inference using mechanistically defined ordinary differential equations (ODE) for gene regulatory networks (GRNs). LASSIM integrates structural knowledge about regulatory interactions and non-linear equations with multiple steady state and dynamic response expression datasets. The rationale behind LASSIM is that biological GRNs can be simplified using a limited subset of core genes that are assumed to regulate all other gene transcription events in the network. The LASSIM method is implement

SUBMITTER: Magnusson R 

PROVIDER: S-EPMC5501685 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature