Lymphocyte Subsets in the Adrenal Glands of Dogs With Primary Hypoadrenocorticism.

ABSTRACT: Primary hypoadrenocorticism, or Addison's disease, is an autoimmune condition common in certain dog breeds that leads to the destruction of the adrenal cortex and a clinical syndrome involving anorexia, gastrointestinal upset, and electrolyte imbalances. Previous studies have demonstrated that this destruction is strongly associated with lymphocytic-plasmacytic inflammation and that the lymphocytes are primarily T cells. In this study, we used both immunohistochemistry and in situ hybridization to characterize the T-cell subtypes involved. We collected postmortem specimens of 5 dogs with primary hypoadrenocorticism and 2 control dogs and, using the aforementioned techniques, showed that the lymphocytes are primarily CD4+ rather than CD8+. These findings have important implications for impr

SUBMITTER: Friedenberg SG 

PROVIDER: S-EPMC5501750 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature