Cerebral responses and role of the prefrontal cortex in conditioned pain modulation: an fMRI study in healthy subjects.

ABSTRACT: The mechanisms underlying conditioned pain modulation (CPM) are multifaceted. We searched for a link between individual differences in prefrontal cortex activity during multi-trial heterotopic noxious cold conditioning and modulation of the cerebral response to phasic heat pain. In 24 healthy female subjects, we conditioned laser heat stimuli to the left hand by applying alternatively ice-cold or lukewarm compresses to the right foot. We compared pain ratings with cerebral fMRI BOLD responses. We also analyzed the relation between CPM and BOLD changes produced by the heterotopic cold conditioning itself, as well as the impact of anxiety and habituation of cold-pain ratings. Specific cerebral activation was identified in precuneus and left posterior insula/SII, respectively, during early an

SUBMITTER: Bogdanov VB 

PROVIDER: S-EPMC5502003 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature