Ontology highlight
ABSTRACT:
SUBMITTER: Klotzsche-von Ameln A
PROVIDER: S-EPMC5502105 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Klotzsche-von Ameln Anne A Cremer Sebastian S Hoffmann Jedrzej J Schuster Peggy P Khedr Sherif S Korovina Irina I Troullinaki Maria M Neuwirth Ales A Sprott David D Chatzigeorgiou Antonios A Economopoulou Matina M Orlandi Alessia A Hain Andreas A Zeiher Andreas M AM Deussen Andreas A Hajishengallis George G Dimmeler Stefanie S Chavakis Triantafyllos T Chavakis Emmanouil E
Thrombosis and haemostasis 20170427 6
We have recently identified endothelial cell-secreted developmental endothelial locus-1 (Del-1) as an endogenous inhibitor of β2-integrin-dependent leukocyte infiltration. Del-1 was previously also implicated in angiogenesis. Here, we addressed the role of endogenously produced Del-1 in ischaemia-related angiogenesis. Intriguingly, Del-1-deficient mice displayed increased neovascularisation in two independent ischaemic models (retinopathy of prematurity and hind-limb ischaemia), as compared to D ...[more]