Neuroligins Nlg2 and Nlg4 Affect Social Behavior in Drosophila melanogaster.

ABSTRACT: The genome of Drosophila melanogaster includes homologs to approximately one-third of the currently known human disease genes. Flies and humans share many biological processes, including the principles of information processing by excitable neurons, synaptic transmission, and the chemical signals involved in intercellular communication. Studies on the molecular and behavioral impact of genetic risk factors of human neuro-developmental disorders [autism spectrum disorders (ASDs), schizophrenia, attention deficit hyperactivity disorders, and Tourette syndrome] increasingly use the well-studied social behavior of D. melanogaster, an organism that is amenable to a large variety of genetic manipulations. Neuroligins (Nlgs) are a family of phylogenetically conserved postsynaptic ad

SUBMITTER: Corthals K 

PROVIDER: S-EPMC5502276 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature