T Cell-Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection.

ABSTRACT: Tuberculosis (TB), caused by Mycobacterium tuberculosis infection, is a leading cause of mortality and morbidity, causing ∼1.5 million deaths annually. CD4⁺ T cells and several cytokines, such as the Th1 cytokine IFN-γ, are critical in the control of this infection. Conversely, the immunosuppressive cytokine IL-10 has been shown to dampen Th1 cell responses to M. tuberculosis infection impairing bacterial clearance. However, the critical cellular source of IL-10 during M. tuberculosis infection is still unknown. Using IL-10 reporter mice, we show in this article that during the first 14 d of M. tuberculosis infection, the predominant cells expressing IL-10 in the lung were Ly6C⁺ monocytes. However, after day 21 postinfection, IL-10-expressi

SUBMITTER: Moreira-Teixeira L 

PROVIDER: S-EPMC5502318 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature