Whole-transcriptome analysis delineates the human placenta gene network and its associations with fetal growth.

ABSTRACT:

Background

The placenta is the principal organ regulating intrauterine growth and development, performing critical functions on behalf of the developing fetus. The delineation of functional networks and pathways driving placental processes has the potential to provide key insight into intrauterine perturbations that result in adverse birth as well as later life health outcomes.

Results

We generated the transcriptome-wide profile of 200 term human placenta using the Illumina HiSeq 2500 platform and characterized the functional placental gene network using weighted gene coexpression network analysis (WGCNA). We identified 17 placental coexpression network modules that were dominated by functional processes including growth, organ development, gas exchange and immune response.

SUBMITTER: Deyssenroth MA 

PROVIDER: S-EPMC5502484 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature