Population-genomic inference of the strength and timing of selection against gene flow.

ABSTRACT: The interplay of divergent selection and gene flow is key to understanding how populations adapt to local environments and how new species form. Here, we use DNA polymorphism data and genome-wide variation in recombination rate to jointly infer the strength and timing of selection, as well as the baseline level of gene flow under various demographic scenarios. We model how divergent selection leads to a genome-wide negative correlation between recombination rate and genetic differentiation among populations. Our theory shows that the selection density (i.e., the selection coefficient per base pair) is a key parameter underlying this relationship. We then develop a procedure for parameter estimation that accounts for the confounding effect of background selection. Applying this method to tw

SUBMITTER: Aeschbacher S 

PROVIDER: S-EPMC5502586 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature