Virus-induced inflammasome activation is suppressed by prostaglandin D₂/DP1 signaling.

ABSTRACT: Prostaglandin D2 (PGD₂), an eicosanoid with both pro- and anti-inflammatory properties, is the most abundantly expressed prostaglandin in the brain. Here we show that PGD₂ signaling through the D-prostanoid receptor 1 (DP1) receptor is necessary for optimal microglia/macrophage activation and IFN expression after infection with a neurotropic coronavirus. Genome-wide expression analyses indicated that PGD₂/DP1 signaling is required for up-regulation of a putative inflammasome inhibitor, PYDC3, in CD11b⁺ cells in the CNS of infected mice. Our results also demonstrated that, in addition to PGD₂/DP1 signaling, type 1 IFN (IFN-I) signaling is required for PYDC3 expression. In the absence of Pydc3 up-regulation, IL-1β expression and,

SUBMITTER: Vijay R 

PROVIDER: S-EPMC5502630 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature