The PF4/PPBP/CXCL5 Gene Cluster Is Associated with Periodontitis.

ABSTRACT: Periodontitis is a common dysbiotic inflammatory disease with an estimated heritability of 50%. Due to the limited sample size of available periodontitis cohorts and the underlying trait heterogeneity, genome-wide association studies (GWAS) of chronic periodontitis (CP) have been unsuccessful in discovering susceptibility factors. A strategy that combines agnostic GWAS with a well-powered candidate-gene approach has the potential to discover novel loci. We combined RNA-seq data from gingival tissues with quantitative trait loci (QTLs) that were identified in a F₂-cross of mice resistant and susceptible to infection with oral bacterial pathogens. Four genes, which were located within the mapped QTLs, showed differential expression. The chromosomal regions across the human ortholo

SUBMITTER: Shusterman A 

PROVIDER: S-EPMC5502958 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature