Phosphodiesterase Type 5 Inhibitors for Premature Ejaculation: A Systematic Review and Meta-analysis.

ABSTRACT:

Context

Phosphodiesterase type 5 inhibitors (PDE5-Is) are prescribed off-label for the treatment of premature ejaculation (PE).

Objective

To systematically review the evidence from randomised controlled trials (RCTs) for PDE5-Is in the management of PE.

Evidence acquisition

Medline and other databases were searched through September 2015. Quality of RCTs was assessed. Intravaginal ejaculatory latency time (IELT) data were pooled in a meta-analysis. Heterogeneity was assessed.

Evidence synthesis

Fifteen RCTs were included. The majority were of unclear methodological quality. Pooled IELT evidence suggests that PDE5-Is are significantly more effective than placebo (231 participants, p<0.00001), that there is no difference between PDE5-Is and selective serotonin re

SUBMITTER: Martyn-St James M 

PROVIDER: S-EPMC5503121 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature